Individuals who might need a lower dose of Tadalista 40 mg (which contains tadalafil as its active ingredient) due to age or health factors include: Older adults: Older adults may be more susceptible to the effects of medications due to age-related changes in metabolism, liver and kidney function, and overall health. As a result, they may require lower doses of tadalafil to achieve the desired therapeutic effect while minimizing the risk of adverse effects. Individuals with liver or kidney impairment: Tadalafil is primarily metabolized in the liver and excreted via the kidneys. Individuals with liver or kidney impairment may have reduced clearance of the medication, leading to higher blood levels and an increased risk of adverse effects. A lower dose of Tadalista 40 mg or less frequent dosing may be necessary in these populations to avoid toxicity. Individuals taking certain medications: Tadalista 40 Mg can interact with other medications, particularly those that inhibit or induce cytochrome P450 enzymes involved in its metabolism. Concomitant use of medications such as alpha-blockers, nitrates, antihypertensives, or potent CYP3A4 inhibitors can increase the risk of adverse effects or decrease the effectiveness of tadalafil. In such cases, a lower dose of Tadalista 40 mg may be recommended to minimize the risk of interactions. Individuals with cardiovascular conditions: Tadalafil can affect blood pressure and cardiovascular function. Individuals with cardiovascular conditions such as coronary artery disease, heart failure, or arrhythmias may be at increased risk of cardiovascular side effects when using tadalafil. A lower dose of Tadalista 40 mg or careful monitoring may be necessary in these populations. Individuals with certain medical conditions: Certain medical conditions, such as retinitis pigmentosa, severe vision loss, or anatomical deformities of the penis, may increase the risk of adverse effects when using tadalafil. A lower dose of Tadalista 40 mg or alternative treatments may be considered in these individuals. It's essential for individuals to discuss their medical history, current medications, and any underlying health conditions with a healthcare provider before starting treatment with Tadalista 40 mg or any medication containing tadalafil. A healthcare provider can provide personalized recommendations and adjust the dosage as needed to ensure safe and effective treatment.