Duratia is a brand name for a medication that contains dapoxetine as its active ingredient. Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) that is primarily used to treat premature ejaculation (PE) in adult men. The mechanism of action of Duratia involves its effects on serotonin levels in the brain.

Here's a breakdown of the mechanism of action of Duratia:

1. 
   

   Serotonin Reuptake Inhibition: Dapoxetine inhibits the reuptake of serotonin, a neurotransmitter, in the synaptic cleft. This means that it prevents the reabsorption of serotonin by the nerve cells that release it.

   
   


2. 
   

   Increased Serotonin Levels: By inhibiting serotonin reuptake, dapoxetine increases the levels of serotonin in the synaptic cleft. This results in enhanced serotonin signaling in certain areas of the brain.

   
   


3. 
   

   Central Nervous System Modulation: The increased levels of serotonin in the central nervous system modulate neuronal activity and influence the ejaculatory process. Serotonin is involved in the regulation of mood, emotions, and various physiological processes, including the control of ejaculation.

   
   


4. 
   

   Delayed Ejaculation: The primary therapeutic effect of dapoxetine is the delay of ejaculation. By influencing serotonin levels and the central nervous system, dapoxetine helps improve control over ejaculation and extends the time it takes to reach climax, thus addressing premature ejaculation.