Duratia is indicated for the treatment of premature ejaculation, which is characterized by ejaculation that occurs with minimal sexual stimulation and before a man desires it, often leading to distress and dissatisfaction. Dapoxetine, the active ingredient in Duratia, works by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter that plays a role in regulating mood and controlling the ejaculation reflex. By inhibiting the reuptake of serotonin, dapoxetine helps delay the ejaculation reflex, allowing men to have better control over when they ejaculate during sexual activity.  Duratia dapoxetine is known for its relatively fast onset of action. It can start working within 1 to 2 hours after ingestion, allowing for spontaneous sexual activity. Unlike some other SSRIs used to treat depression and anxiety disorders, dapoxetine has a short duration of action. It is designed to be taken as needed and is not intended for daily use. Duratia is typically taken 1 to 3 hours before anticipated sexual activity. The medication's effects can last for a limited time, generally up to a few hours, which is sufficient to improve control over ejaculation during sexual activity.