Combining Vriligy 60 mg with nitroglycerin or other nitrates is contraindicated and can lead to potentially serious interactions and adverse effects. Both Vriligy (dapoxetine) and nitroglycerin exert effects on the cardiovascular system, and their concurrent use can result in severe hypotension (low blood pressure), syncope (fainting), and other cardiovascular complications. Nitroglycerin is a medication commonly used to treat angina (chest pain) and heart failure. It works by dilating blood vessels, which can lead to a rapid decrease in blood pressure. When nitroglycerin is used concurrently with medications like Vriligy, which affect blood pressure and may also cause vasodilation, the combination can lead to a dangerous drop in blood pressure, potentially resulting in dizziness, fainting, or even cardiovascular collapse. Therefore, it's crucial to avoid taking Vriligy 60mg (dapoxetine) with nitroglycerin or any other nitrates. If you are prescribed both medications for different conditions, it's essential to inform your healthcare provider about all medications you are taking to avoid potentially harmful interactions. Your healthcare provider can provide guidance on the safe use of medications and may recommend alternative treatments or adjustments in dosages to minimize the risk of adverse effects. If you experience symptoms such as dizziness, lightheadedness, fainting, or a sudden drop in blood pressure while taking Vriligy 60 mg or nitroglycerin, seek medical attention immediately. These symptoms may indicate a serious interaction between the medications and require prompt evaluation and management by a healthcare professional.