Fildena Super Active contains sildenafil citrate and is primarily used to treat erectile dysfunction (ED) in men. Like other medications containing sildenafil, Fildena Super Active can interact with certain medications, potentially leading to adverse effects or reduced effectiveness. It's essential to inform your healthcare provider about all medications you are taking, including prescription medications, over-the-counter drugs, and supplements, to avoid interactions. Here are some common interactions to be aware of: Nitrates: Fildena Super Active should not be taken with nitrates, which are commonly used to treat chest pain (angina) and heart conditions such as coronary artery disease. Combining sildenafil with nitrates can lead to a severe drop in blood pressure, potentially causing dizziness, fainting, or even a heart attack or stroke. Nitrate-containing medications include nitroglycerin, isosorbide mononitrate, and isosorbide dinitrate. Alpha-blockers: Alpha-blockers are medications used to treat high blood pressure (hypertension) and benign prostatic hyperplasia (BPH). Combining sildenafil with alpha-blockers can also lead to a significant drop in blood pressure, increasing the risk of dizziness, fainting, or low blood pressure. Common alpha-blockers include tamsulosin, doxazosin, and alfuzosin. Other antihypertensive medications: Sildenafil can enhance the hypotensive (blood pressure-lowering) effects of other antihypertensive medications, potentially leading to excessive blood pressure lowering. It's important to monitor blood pressure closely if taking Fildena Super Active with other antihypertensive drugs. Protease inhibitors: Protease inhibitors, used to treat HIV/AIDS, can increase the levels of sildenafil in the blood, leading to an increased risk of sildenafil-related side effects. Dose adjustments may be necessary when combining sildenafil with protease inhibitors such as ritonavir, saquinavir, or atazanavir. Other medications metabolized by the liver: Sildenafil is metabolized primarily in the liver by the cytochrome P450 enzyme system. Drugs that inhibit or induce this enzyme system may affect the metabolism of sildenafil, potentially altering its effectiveness or increasing the risk of side effects. Examples of medications that may interact with sildenafil in this way include certain antibiotics, antifungal medications, and antiepileptic drugs. Grapefruit juice: Grapefruit juice can increase the levels of sildenafil in the blood, potentially enhancing its effects and increasing the risk of side effects. It's advisable to avoid consuming grapefruit juice while taking sildenafil. It's essential to discuss any concerns or questions about potential drug interactions with your healthcare provider before starting Fildena Super Active or any other medication. They can provide personalized guidance based on your individual health status and medication regimen to ensure safe and effective treatment of erectile dysfunction.